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Indeed, genetic and pharmacological replenishment of NAD + improves the age-related biologic function and increases lifespan at least in worms and mice

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Chemosphere 68:731743 Gagn F, Blaise A, Andr C, Pellerin J (2007b) Implication of site quality on mitochondrial electron transport activity and its interaction with temperature in feral Mya areneria clams from the Saguenay fjord