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Whereas expression of the enzymatically inactive mutants did not significantly affect the abundancy of cellular ATP comparing to cells transfected with the empty vector, expression of wild-type Ceg14 led to ~90% reduction

Importance of the intestine as a site of metformin-stimulated glucose utilization

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Key roles include: Antioxidant defense: Neutralizes free radicals and reactive oxygen species (ROS) before they damage cell membranes, proteins, and DNA

Neuroreport 9 , 37253729 (1998)