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This effect exerted was found to be mediated by the subsequent activation of the PI3K/Akt/GSK3 signaling pathway, followed by the activation of IP3R in the endoplasmic reticulum that resulted in the elevation of intracytoplasmic Ca 2+ , which finally culminated in mitochondria-dependent apoptosis

Pickart detailed that GHK-Cu can [5]: Reduce deep wrinkles and fine lines Tighten skin Improve skin density and elasticity Reverse the thinning of aged skin Protect skin cells from UV radiation Improve overall skin appearance Due to its properties, GHK-Cu is frequently included in cosmetic products, including anti-aging face creams [1]

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UK, LQ, PW and JT proofread the manuscript

This leads to a more luminous, even complexion