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The peptide P4-9 did potentiate the effect of antibiotic novobiocin in a process the authors referred to as Post-Antibiotic Effect-associated Permeabilization. Similarly, administration of other antibiotics such as macrolide, cephalosporins, ciprofloxacin, rifampin, and fosfomycin after the withdrawal of P4-9 also showed Post-Antibiotic Effect-associated Permeabilization at a varying magnitude
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However, the predominance of in vitro and acute in vivo models highlights the need for systematic evaluation of long-term safety, biodistribution, and translational relevance in clinically relevant neurological settings [151153]
10.3390/ijms222212368 117 van NorrenD.VosJ
Hormonal manipulation, treatment, and surgery Chronic ACTH treatment was performed using Synachten 1 mg/mL diluted in PBS 1 (Gibco, #10010023) to 0.25 mg/mL
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