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The fetus is essentially bathed in caffeine continuously, at concentrations equal to or higher than the mothers, with no ability to clear it

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Nevertheless, DFOs clinical applicability is constrained by poor BBB penetration and non-oral administration route, prompting the development of modified delivery systems(e.g., DFO-gold nanoparticle conjugates, NCT05022472) currently under preclinical optimization

demonstrated that a 50 ppm LC supplementation in gestation sow diet improved muscle fiber development by increasing the leanness and muscling of the fetal piglet