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While L-carnitine shows some evidence in previous studies conducted with migraine in combination with other supplements, additional studies are needed to confirm the role of ALA as monotherapy and in combination with L-carnitine

After analyzing 31 polymorphisms in 11 genes, it has been discovered that in presence of the C allele in SLC22A4 (OCTN1 rs1050152), and the two minor alleles (G) in SLC22A5 (OCTN2 rs2631367 and rs2631372) the time to progression was significantly improved ( General Features of OCTN1 (SLC22A4) and Implications in Cancer Organic cation transporter OCTN1 is another member of the SLC22 family

doi: 10.1186/s12883-019-1433-0 23 HoldenSMaksoudREaton-FitchNCabanasHStainesDMarshall-GradisnikS

CPT1A , carnitine palmitoyltransferase 1A