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Ethics declarations Ethical approval Animal studies were conducted in accordance with the ethical guidelines for investigations in laboratory animals and were approved by the Ethical Committee of Faculty of Pharmacy, Mansoura University, Egypt, which is in accordance with the Principles of Laboratory Animal Care (NIH publication no

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In www.ncbi.nlm.nih.gov

Several complex signal transduction pathways and cellular processes have been implicated in APAP hepatotoxicity, including those involving c-Jun N-terminal kinase, Nuclear factor E2-related factor 2 (Nrf2), p53, endoplasmic reticulum stress, autophagy, and sterile inflammation (Chowdhury et al

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In summary, ED is a complex disease associated with multiple risk factors, and effective therapy should be taken according to the etiology and individual conditions