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In humans, this immunological immaturity tends to be present until the end of the first trimester and so provides a succinct window of opportunity. Another potential biological advantage is that the early gestational period is the only time in life during which large-scale migration of hematopoietic stem cells (HSCs) to tissue compartments occurs

But many don't respond

Given the importance of having sufficient amounts of vitamin B12 in your body, it comes as no surprise that vitamin B12 IV therapy is becoming increasingly popular

2015 Sep;115(9):1949-57

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1c and the monothiol mechanism (i) from Fig