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The intestinal epithelial cells are frequently attacked during chemotherapy treatments due to their ability to proliferate quickly (Dahlgren et al

Xiong J, Wang N, Zhong HJ, Cui BW, Cheng S, Sun R, et al

J Transl Med 8: 39 Spitz DR, Sim JE, Ridnour LA, Galoforo SS, Lee YJ (2000) Glucose deprivationinduced oxidative stress in human tumor cells

Without IGFBP binding, IGF-1 LR3 remains in free, receptor-accessible form for 5672 hours substantially longer than native IGF-1's 1020-minute half-life when not IGFBP-bound

doi: 10.1007/s10535-015-0542-x
