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However, juvenile or adult onset manifestations characterized mainly by ataxia, dementia, and psychosis have been described [2, 4]

(2003) Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance

While not a complete solution to muscle loss, it offers some protective effect when combined with adequate dietary protein and resistance training

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