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NAC is highly hydrophilic and has recently been identified as a transporter substrate and, as such, has very limited ability to cross the intact bloodbrain barrier (BBB) hampering successful translation [5]

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The liver, due to its strong phagocytic and filtering functions, and the absence of an impermeable basement membrane, leads to a large accumulation of LNPs in the liver, which may not only cause liver toxicity and liver function damage but also affect the therapeutic effects of lung cancer