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Approximately 50-70% of adult and pediatric SLE patients have an upregulated IFN signature, a cluster of IFN-stimulated genes, that correlates with disease activity and severity (122)

A 2021 systematic review and meta-analysis found that COPD patientswhose antioxidant defenses are lowimproved with glutathione therapy

Individual metabolism affects antioxidant levels in the body

Respiratory and haematological systems may be indirectly affected through androgen-induced erythropoiesis and fluid retention

GSH levels were also found to be decreased in the frontal cortex of patients with AD, and the GSH reductions in these regions were correlated with the decline in cognitive functions [100]