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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

High IGF-1 levels could compete for binding to the IGF-1R thus reversing the inhibitory effect of IGF-1R-targeted antibodies [84]

Final Results of RTOG 0246: A Phase II Study of Selective Surgical Resection for Locoregionally Advanced Esophageal Cancer Treated With Paclitaxel Based Chemoradiation Regimen

This comprehensive in vitro study used human liver microsomes and expressed human CYPs to characterize the oxidation of tamoxifen, showing that the conversion of tamoxifen to its secondary metabolite endoxifen occurs through two primary metabolites and is predominantly mediated by CYP2D6, CYP3A4 and CYP3A5