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doi: 10.2174/1389450121999201117115717 39 Desbois-MouthonCCadoretABlivet-Van EggelpolMJBertrandFCherquiGPerretCet al

Notably, organismal circulating CYS 2 levels can be affected by biological context, feeding state and nutritional composition 59,60 , and CYS 2 supplementation has been found to increase tumour xCT activity in a mouse model of NRF2-activated NSCLC 9 , suggesting that interventions to increase circulating CYS 2 might selectively impact NRF2-driven tumours by driving excess CYS stress

Diehl JA,Ron D,Koumenis C

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