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This could theoretically affect DNA methylation, gene expression, and other processes dependent on methylation
Usually IGF-1 deficiency is associated to GH resistance or GH insensibility states
doi: 10.1073/pnas.0802917105

The metabolic changes come from cellular-level effects rather than artificially elevated sympathetic tone
When NNMT levels are high, its harder for people to lose weight
No statistically significant increases in chromosomal aberrations were observed in CHO cells at any tested concentration
