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doi:10.1155/2020/9210261 Majda A, Zalewska-Puchala J, Bodys-Cupak I, Kaminska A, Kurowska A, Suder M

However, contrary to expectations, the deletion of the Nfe2l2 gene had a moderate impact on the course of the disease in SOD1 G93A mice and negatively affected only a few Nrf2-regulated antioxidant enzymes, thus suggesting that several Nrf2-target genes can also be regulated independently of Nrf2 in ALS mice [270, 271]

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however, it is rarely used in human patients except for the hyperthermic intraperitoneal chemotherapy procedure

Epigenetic mechanisms contribute to intraindividual variations of drug metabolism mediated by cytochrome P450 enzymes

Moreover, protein interaction analyses identified PIEZO1-TMBIM6 as an upstream regulator of PHB2 phosphorylation, with the nano-formulation modulating this network to preserve cardiac contractility and mitigate DOX-induced structural remodeling