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Studies indicate that apolipoprotein E can cause cholesterol to migrate from the core of LNPs to the outer lipid layer, potentially altering the surface properties of LNPs

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This decline contributes to many age-related changes like decreased muscle mass, increased body fat, reduced bone density, and lower energy levels

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doi: 10.3389/fmicb.2018.00757 186 StolfiCMarescaCMonteleoneGLaudisiF