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For example, in the FY 2019 MedPAR data used for the FY 2021 IPPS/LTCH PPS final rule, cases that we identified as clinical trial cases (using our proxy of standardized drug charges of less than $373,000) that did not contain ICD-10-CM diagnosis code Z00.6 comprised 18% of all cases that grouped to MS-DRG 018

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However, the DNA glycosylase repair system fails due to low folate concentration and high concentration of Hcy, resulting in chromosomal damage and subsequent promotion of carcinogenesis [166]

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These reactions involve a wide array of foreign chemicals and endogenous reactive intermediates, leading to the formation of various thioether conjugates and thioesters

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