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Ultimately, unmitigated oxidant stress contributes to increased fatty acid desaturation, oxidation and migration to the membrane of oxidized proteins (e.g., peroxiredoxin 2 [34]), vesiculation of oxidized proteins [12] and lipids [164], a process that promotes the loss of the RBC discocytic phenotype and the acquisition of an echinocytic, spheroechinocytic and spherocytic morphology [141,143,165,166]

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Several other factors including aluminium or pesticide exposures, environmental pollution, traumatic brain injury (Graham and Sharp, 2019), variation in microglial cell density (Muzio et al., 2021), etc

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