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Nasal spray delivers lower bioavailability than injection, typically 40-60% compared to 80-95% for subcutaneous administration

While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest

Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

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Peptides play a crucial role in promoting fat loss through several interconnected mechanisms

1 and Supplementary Figs