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Most interestingly, HDL have been demonstrated to transport a wide-variety of exogenous non-host small RNAs, including rRNA and tRNA fragments derived from bacterial and fungal species present in the microbiome and environment (774).The size of HDL is determined by the amount of CE and triglyceride (TG) in the hydrophobic core, and HDL is generally separated into 5 sub-classes based on size

3 The role of miRNA in the injury of UC intestinal mucosal barrier (Figure 1) 3.1 miRNA disruption of the intestinal epithelial barrier is an early event in UC intestinal The intestinal epithelial barrier comprises tightly connected intestinal epithelial cells (IEC)

doi: 10.1371/journal.ppat.1000758 229 LevitzS

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