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Additionally, there is a non-enzymatic antioxidant system that includes compounds such as ergothioneine, vitamin C, vitamin E, glutathione, melatonin (MT), alpha-lipoic acid (ALA), carotenoids, and trace elements like copper, zinc, and selenium (Se)

The pineal gland produces natural peptides that decline with age, affecting circadian rhythm, immune function, and cellular repair signaling

Molecular and cellular basis of depigmentation in vitiligo patients

doi:10.1016/S0140-6736(20)32667-2

These findings raise awareness not only about the cytotoxic effects of the drug but also about its potential to contain the spreading of cancer by reducing invasion and migration ( 4.5 Taxanes, molecular cascades, and targeted signaling pathways Overall, paclitaxel inhibits the activation of Akt (downstream effector of the PI3K pathway), thus reducing the phosphorylation of mTOR and decreasing cell proliferation at the expense of increased cell death