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For application after microneedling: 0.05% (500 ppm), because open microchannels increase absorption up to 10-fold

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Ligands may also bind elsewhere, however, as is the case for bulkier ligands (e.g., proteins or large peptides), which instead interact with the extracellular loops, or, as illustrated by the class C metabotropic glutamate receptors (mGluRs), the N-terminal tail

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