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These classic treatments may emphasize several limitations, including poor responses to treatment, potential drug interactions, hepatic and renal toxicity, and even a significant risk of skin malignancy and teratogenicity [28]

Therefore, it would be important to treat LN by appropriate intervention in macrophage pathways associated with energy metabolism to inhibit M1 polarization and promote M2 polarization through the use of suitable drugs at the right time and in a moderate manner

S., Wang, S

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