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Skirecki T, Hoser G, Domagala-Kulawik J, et al

These enzymes have been extensively studied in eukaryotes (Zong et al., 2024)

Superoxide production The production of superoxide by TGR was determined by monitoring reaction of superoxide with pyrogallol red 80

Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils

During the progression of MASH, the accumulation of lipotoxic and reactive oxygen species induce hepatocellular injury, inflammasome activation, release of proinflammatory chemokines with subsequent monocyte infiltration and activation of macrophages and hepatic stellate cells that drive steatohepatitis and hepatic fibrosis 2,3,4

This finding provides compelling evidence that GGCT reduces ROS primarily by regulating Gln shunting to GSH, rather than through modulating energy metabolism pathways to exert its pro-proliferative effects