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Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant

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This dual action, increasing fat breakdown while simultaneously reducing new fat formation, has been observed in multiple rodent adipocyte models and provides a mechanistically distinct experimental profile compared to compounds that affect only one arm of fat metabolism

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Yi Z, Jiang L, Zhao L, Zhou M, Ni Y et al (2019) Glutathione peroxidase 3 (GPX3) suppresses the growth of melanoma cells through reactive oxygen species (ROS)-dependent stabilization of hypoxia-inducible factor 1- and 2-