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2 The pathophysiology of Parkinsons disease Parkinsons disease, first described by James Parkinson in 1817, is a complex, age-related, progressive, and multisystem neurodegenerative condition associated with dopaminergic neuronal loss and formation of -synuclein (-Syn) protein aggregation in neurons of the substantia nigra (SN) (Morris et al., 2024)

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All eligible patients were assigned at random to one of the three groups, each consisting of 15 patients: the control group , where patients received the standard psoriatic treatment of topical steroids (Triamcinolone acetonide 0.5%, once daily before sleep), salicylic acid (2% once daily), and Urea (10% twice daily) [34]

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Here, we use induced-pluripotent stem cells derived from a Gdap1 knockout mouse model to better understand the molecular and cellular phenotypes of the disease caused by the loss-of-function of this gene