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The resistant parasites also exhibit improved tolerance to host defense mechanisms, such as nitrosative stress, and evade immune responses through increased interleukin-10 (IL-10) production, which facilitates immune evasion ( FIGURE 3 In addition to drug efflux and membrane adaptations , L

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The APE1 inefficiently cleaves but recruits various transcription factors to activate downstream genes, such as vascular endothelial growth factor (VEGF) and endonuclease IIIlike protein 1 (NTHL1) [95]

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