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Towards Cellular Targets for Therapy in SCA3: Lessons from Preclinical Models So far, we have proposed that the primary pathogenic mechanism in SCA3 is indeed the loss of normal quality control of protein folding and interactions, therefore compromising their function

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Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation

[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Lebeau G., Lagrave A., Ogire E., Grondin L., Seriacaroupin S., Moutoussamy C., Mavingui P., Hoarau J.J., Roche M., Krejbich-Trotot P., et al

MTD, maximum tolerated dose (10-mg or 15-mg)

Peripheral neuropathy affects millions of people and is a growing concern, particularly amongst individuals living with diabetes and those who have long term nutritional absorption issues