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The origins of a concept: the protease-antiprotease imbalance hypothesis

doi: 10.1155/2018/5828120

(2025) found that at low concentrations, fluoxetine consistently reduced sperm motility while promoting fluctuations in cellular reactive oxygen species (ROS) levels and sperm capacitation, without affecting sperm viability, mitochondrial membrane potential, the acrosome reaction, or chromatin/DNA integrity as shown in Figure 1

8 weeks: ~3 vials 12 weeks: ~4 vials 16 weeks: ~6 vials Insulin Syringes (U-100, 1 mL) Per week (once daily): 7 syringes 8 weeks: 56 syringes 12 weeks: 84 syringes 16 weeks: 112 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 10 mg vial for reconstitution

Lancet 376 , 20182031 (2010)

Veterinary Surgery, 32(6), 515-523