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ALDH2 has a half-saturation constant for formaldehyde of 320 M 9

More than half of patients taking these drugs experience an acneiform eruption
10.1021/tx010052h 139 ZhouH.BrockJ.LiuD.BoardP

And the math is simpler when you are learning to calculate concentrations for the first time

Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, Phase 3 trial

37 They are used when 2 ligands and SNRIs are ineffective or contraindicated
