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Description

ANO1: Anoctamin 1 TME: Tumor microenvironment HMG-CoA: 3-hydroxy-3-methyl-glutaryl-CoA IPP: Isopentenyl pyrophosphate GPP: Geranyl pyrophosphate FPP: Farnesyl pyrophosphate SREBP2: Sterol regulatory element-binding protein 2 LXR: Liver X receptor ER: Endoplasmic reticulum SCAP: SREBP cleavage-activating protein INSIG: Insulin-induced gene S1P: Site-1 protease S2P: Site-2 protease HMGCR: HMGCoA reductase LDL: Low-density lipoprotein LDLR: Low-density lipoprotein receptor NPC1L1: Niemann-Pick type C1-like 1 NPC: Niemann-Pick C PCSK9: Proprotein convertase subtilisin/kexin type 9 SRE: Sterol regulatory elements CEs: Cholesterol esters ACAT: Acyl-CoA: cholesteryl acyltransferase LDs: Lipid droplets ABC: ATP-binding cassette ABCA: ATP-binding cassette subfamily A member ABCB: ATP-binding cassette subfamily B member ABCG: ABC subfamily G member HDL: High-density lipoprotein CRC: Colorectal cancer ENSA: Gene alpha-endosulfine TNBC: Triple-negative breast cancer PDAC: Pancreatic ductal adenocarcinoma XBP1: X-box binding protein 1 HCC: Hepatocellular carcinoma TFCP2: Transcription factor CP2 27HC: 27-hydroxycholesterol RCC: Renal cell carcinoma ccRCC: Clear cell renal cell carcinoma ZMYND8: Zinc finger MYND-type containing 8 ER-BC: Estrogen receptor-negative breast cancer GPER: G protein-coupled estrogen receptor GGPP: Geranylgeranyl diphosphate SQLE: Squalene epoxidase CRPC: Castration-resistant prostate cancer GC: Gastric cancer CH25H: Cholesterol 25-hydroxylase MMP: Matrix metalloproteinase SOAT1: Sterol O-acyltransferase 1 CRABP-II: Cellular retinoic acid-binding protein II AR: Androgen receptor 5-FU: 5fluorouracil PD-L1: Programmed death ligand 1 CRAC: Cholesterol-recognition amino acid consensus ER+: Estrogen receptor-positive EGFR-TKIs: Epidermal growth factor receptor tyrosine kinase inhibitors NSCLC: Non-small cell lung cancer TIICs: Tumor-infiltrating immune cells TIME: Tumor immune microenvironment NK: Natural killer TAMs: Tumor-associated macrophages MDSCs: Myeloid-derived suppressor cells DCs: Dendritic cells TILs: Tumor-infiltrating lymphocytes CTLs: Cytotoxic T lymphocytes MHC-I: Major histocompatibility complex class I CAR: Chimeric antigen receptor TCR: T-cell receptor IL-9: Interleukin-9 NKT: Natural killer T mTORC2: Mammalian target of rapamycin complex 2 CXCR2: CXC chemokine receptor 2 HIF-1: Hypoxia-inducible factor-1 GBM: Glioblastoma multiforme GPR: G-protein-coupled receptor CCR7: CC chemokine receptor-7 ROS: Reactive oxygen species DNMT3A: DNA methyltransferase 3A RECK: Reversion-inducing-cysteine-rich protein with Kazal motifs HIFs: Hypoxia-inducible factors PKB: Protein kinase B CAFs: Cancer-associated fibroblasts YAP: Yes-associated protein ECM: Extracellular matrix EMT: Epithelial-mesenchymal transition CXCL1/2/8: C-X-C motif chemokines 1/2/8 CCL2/7: C-C motif chemokines 2/7 TAZ: PDZ-binding motif TFEB: Transcription factor EB APMAP: Adipocyte plasma membrane-associated protein ERK1/2: Extracellular-regulated protein kinase 1/2 NAFLD: Non-alcoholic fatty liver disease FDPS: Farnesyl diphosphate synthase FDA: Food and Drug Administration OSC: Oxidosqualene cyclase ApoE: Apolipoprotein-E NASH: Nonalcoholic steatohepatitis SERMs: Selective estrogen receptor modulators NF: Nuclear factor PD-1: Programmed cell death protein 1 CSC: Cancer stem cell PFS: Progression-free survival DFS: Disease-free survival OS: Overall survival SAMS: Statin-associated muscle symptoms We apologize to those colleagues whose important work could not be cited due to space constraints

Feng Y, Yuan P, Guo H, Gu L, Yang Z, Wang J

RIGUOUS TESTING BEYOND THE STANDARD - Made in Germany to the highest standards (ISO, HACCP certification), Gloryfeel products also undergo rigorous stability tests to ensure consistent ingredient efficiency throughout their expiration date and set new industrial standards

First, the small sample sizedue to the extreme rarity of MSmay limit the generalizability of our results, and future studies with expanded cohorts are needed for validation