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Patients who establish care at Perfect B and are on a stable protocol may be able to continue with follow-up check-ins without returning for every appointment, depending on their specific protocol and clinical needs

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Cuprizone induces mitochondrial injury and oxidative stress by increasing mitochondrial production of superoxide anions 4 , reducing copper-dependent cytochrome c oxidase and monoamine oxidase activity 1 , decreasing copper-zinc superoxide dismutase 5 and glutathione 6 antioxidant activity, and inhibiting electron transport chain complex IV 7

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doi:10.5009/gnl18490 Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Vrcic H, Sebecic B