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The reductive shifts in the brain cytoplasmic pyruvate/lactate ([NAD + ]/[NADH]) and malate/pyruvate ([NADPH]/[NADP + ]) during the stroke may provide neuroprotection, in part through increasing CBF, similar to the reductive shifts that occur with fasting as described above

Elucidating compound mechanism of action by network perturbation analysis

Similarly, S-nitrosylation of serine racemase inhibits the formation of the NMDA receptor coagonist, D-serine, which would decrease NMDA receptor activity [301]

In addition, certain AMPs inhibit various cellular processes, including transcription, translation, and cell wall synthesis (Jhaveri et al

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Considering that carotid intima-media thickness (CIMT) is a critical marker of early atherosclerotic lesions, the positive correlation between elevated levels of BCAAs and increased CIMT suggests a potential role for BCAAs in the early development of atherosclerosis (53)