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10.1002/bmc.4991 [DOI] [PubMed] [Google Scholar] 33.Liu X, Zheng P, Zhao X, Zhang Y, Hu C, Li J, et al

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Small dense low-density lipoprotein Small dense LDL (sdLDL) are a lipoprotein fraction with low density, but more atherogenic properties than the so-called large buoyant LDL (lbLDL), due to their small size and significant modification of their particles, mainly by oxidation, and easy penetration through endothelial cells (transcytosis) into the subendothelial space of the arterial membrane, where they are extensively bound by macrophage scavenger receptors and absorbed leading to the formation of foam cells

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It has been experimentally demonstrated that fasting and protein-free dieting, which are the cornerstones of UCD hyperammonemia management, lead to a decrease in NAG activity following a down-regulation mechanism and increased the activity of other downstream enzymes [48]