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A phase 2 clinical trial assessing the efficacy and safety of pembrolizumab and radiotherapy in patients with metastatic triple-negative breast cancer

The APE1 inefficiently cleaves but recruits various transcription factors to activate downstream genes, such as vascular endothelial growth factor (VEGF) and endonuclease IIIlike protein 1 (NTHL1) [95]

Beyond its effects on the central nervous system, DSIP has been detected in peripheral organs, blood, cerebrospinal fluid, and even human breast milk, indicating a systemic physiological role

Conclusion: Innate antioxidant proteins like sirtuin and sestrin play a vital role in enhancing immunity

TargetP2.0 (T) [46], LOCALIZER (L) [47] and PredAlgo (P) [48] predictions (Additional file 1 Table S1) indicate highly variable targeting of the multiple DHAR paralogs (M, mitochondria

ROS may also mediate metabolism reprogramming ( Classical strategies include direct/indirect HIF targeting and interference in upstream/downstream HIF regulators/signaling pathways