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Digestive issues may further reduce the effectiveness

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slow 8-week regimens brought it to 0-3.8%, near placebo, at no efficacy cost (Frias 2020): Frias Lancet 2018

If you're taking a vitamin supplement for any type of vitamin deficiency, you should try to take it at a time when your body can best

Due to the instability of vitamin B12, the admixture of other medicinal substances can cause the vitamin to lose its effectiveness