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In contrast to these findings, 8 weeks of progressive RT (3 sets of 812 climbs, 50%100% of MCL) on alternating days in aging rats observed increased hippocampal protein expression of TNF- and IL-1 (Vilela et al., 2017)

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This leads to cell cycle arrest, senescence, or apoptosis

Synaptic Versus Extrasynaptic NMDA Receptor Signalling: Implications for Neurodegenerative Disorders. Nature Reviews

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ATP produced by the reaction phosphorylates glucose to glucose-6-phosphate (G6P) by hexokinase, which is oxidized by NADP + in the presence of G6P-dehydrogenase, yielding NADPH