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Accordingly, SFN significantly inhibited the activation of untransformed human T-cells derived from healthy donors or RA patients, and downregulated the expression of the transcription factor RORt, and the T H 17-related cytokines IL-17A, IL-17F, and IL-22, which play a major role within the pathophysiology of many chronic inflammatory/autoimmune diseases

These lifestyle factors can help reduce oxidative stress and support overall well-being

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10.1172/JCI140100 41 ElgogaryA.XuQ.PooreB.AltJ.ZimmermannS

In this section, we explore potential therapeutic strategies reported to date, discussing their practical applications and limitations in OA, and then offer prospects for future investigations