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Gene-based interventions are also being explored, including the delivery of plasmids or viral vectors encoding antioxidant enzymes (e.g., SOD2, catalase, Nrf2) directly to vascular tissues, or CRISPR-based activation of protective genes [470,471,472,473]

[DOI] [PubMed] [Google Scholar] 41.Reuter S., Gupta S.C., Chaturvedi M.M., Aggarwal B.B

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In a 12-week study in NAFLD patients, every-other-weekly administration of up to 100 mg BFKB8488A, the highest adequately tolerated dose, reduced liver fat by about 40%, serum triglycerides and Pro-C3 by up to 25 to 30% from baseline, while increasing adiponectin by up to 40% and HDL-cholesterol by up to 20% (301)