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However, these benefits are more plausibly interpreted as downstream consequences of improved metabolic and inflammatory milieus, rather than as effects directly targeting uric acid metabolism.In addition, these medications can cause adverse reactions such as water and sodium retention and weight gain, necessitating careful consideration of the patients cardiac function status

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Despite these insights, most clinical trials fail to stratify outcomes by sex, obscuring gender-specific mechanisms

In hair testing for adults, neurological effects are seen at 50 ug/g

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